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Publications

We aim to publish scientific stories that challenge and broaden our current understanding of the neural mechanisms of behavior - rather than publishing not to perish.

Research Highlights

Full List of publications (# co-first, *Lead)

2024 & in press

1. Zachry, J.E.#, Kutlu, M.G.#, Patel, D.D., Gaidici, A., Melugin, P.R., Isiktas, A.U., Yoon, H.J., Joffe, M.E., Cai, D.J., Grueter, B.A., Conn, P.J., Calipari, E.S. (2024). Accumbal D1 and D2 medium spiny neurons have distinct and valence-independent roles in learning. Neuron, 112(5), 835-849.

2.  Rinker, J., Hoffman, M., Knapp, J., Wukitsch, T.J., Kutlu, M.G., Calipari, E.S., McMahan, C.S., Baker, G.H., Woodward, J.J., Mulholland, P.J. Prelimbic neuron calcium activity predicts perceived hedonic value across drinking solutions and ethanol dependent states in mice. Biorxv.

2023

1. Dinckol, O., Zachry, J.E., Kutlu, M.G.* (2023). Nucleus accumbens core single cell ensembles bidirectionally respond to experienced versus observed aversive events. Scientific Reports, 13, 22602.

2. Kutlu, M.G., Tat, J., Zachry, J.E., Calipari, E.S.  (2023). Dopamine release at the time of a predicted aversive outcome causally controls the trajectory and expression of conditioned behavior. Cell Reports, 42(8). Link

2022

1. Kutlu, M.G.#, Zachry, J.E.#, Melugin, P.R.#, Cajigas, S.A., Isiktas, A., Siciliano., C.A., Schoenbaum, G., Sharpe, M.J., Calipari, E.S. (2022). Dopamine signaling in the nucleus accumbens core mediates latent inhibition. Nature Neuroscience. Link

2021

1. Kutlu, M.G., Zachry, J.E., Melugin, P.R., Cajigas, S.A., Chevee, M.F., Kelly, S.J., Kutlu, B., Tian, L., Siciliano., C.A., Calipari, E.S. (2021). Dopamine release in the nucleus accumbens core signals perceived saliency. Current Biology. 31(21), 4748-4761. Link

2. Goldberg, L.R., Kutlu, M.G., Zeid, D., Seemiller, L.R., and Gould, T.J. (2021). Systems genetic analysis of nicotine withdrawal deficits in hippocampus-dependent learning. Gene, Brain and Behavior, 20(6), e12734.

3. Badimon, A., Strasburger, H.J., Ayata, P., Chen, X., Nair, A., Ikegami, A., Hwang, P., Chan, A.T., Graves, S.M., Uweru, O.J., Ledderose, C., Kutlu, M.G., Wheeler, M.A., (…) Calipari, E.S., Kenny, P.J., Eyo, U., Colonna, M., Quintana, F.J., Wake, H., Gradinaru, V., Schaefer, A. (2020). Negative feedback control of neuronal activity by microglia. Nature, 586, 417-423.

4. Lopez, A., Johnson, A.R., Euston, T.J., Nolan, S.O., Brady, L.J., Thibeault, K.C., Kutlu, M.G., Kelly, S.J., Kondev, V., Melugin, P., Chuang, E., Siciliano, C.A., Kiraly, D.D., Calipari, E.S. (2021). Cocaine self-administration induces divergent protein expression in the nucleus accumbens of male and female mice to eliminate basal sex differences. Communications Biology, 4(1), 1-13.

2020

1. Kutlu, M.G.#, Zachry, J.E.#, Brady, L., Melugin, P., L.J., Sanders, C., Tat, J., Johnson, A.R., Lopez, A., Siciliano., C.A., Calipari, E.S. (2020). A novel multidimensional reinforcement task in mice elucidates sex-specific behavioral strategies. Neuropsychopharmacology, 45(9), 1463-1472. Link

 

2. Cole, R., Zimmerman, M., Matchanova, A., Kutlu, M.G., Gould, T.J., Parikh, V. (2020). Cognitive rigidity and BDNF-mediated frontostriatal glutamate neuroadaptations during spontaneous nicotine withdrawal. Neuropsychopharmacology, 45, 866-876.

3. Lopez, A., Johnson, A.R., Kunnath, A.J., Zachry, J.E., Thibeault, K.C., Kutlu, M.G., Siciliano, C.A., Calipari, E.S. (2020). An optimized procedure for robust volitional cocaine intake in mice. Experimental and Clinical Psychopharmacology.

2019

1. Goldberg, L.R., Zeid, D., Kutlu, M.G., Cole, R., Lallai, V., Sebastian, A., Albert, I., Fowler, C., Parikh, V., and Gould, T.J. (2019). Paternal nicotine enhances fear memory, reduces nicotine self-administration and alters hippocampal genetic and cholinergic function in subsequent generations. Addiction Biology, e12859.

 

2. Johnson, A.R., Thibeault, K.C., Lopez, A., Peck, E.G., Sands, L.P., Sanders, M.C., Kutlu, M.G., Calipari, E.S. (2019). Cues play a critical role in estrous cycle-dependent enhancement of cocaine reinforcement. Neuropsychopharmacology, 44(7), 1189-1197.

 

3. Thibeault, K.C. , Kutlu, M.G., Sanders, M.C., Calipari, E.S. (2019). Cell-type and projection-specific dopaminergic encoding of aversive stimuli in addiction. Brain Research, 1713, 1-15.

2018

1. Kutlu, M.G., Connor, D.A., Tumolo, J.M., Cann, C., Garret, B., & Gould, T.J. (2018). Nicotine modulates contextual fear extinction through changes in ventral hippocampal GABAergic function. Neuropharmacology, 142, 192-200.

2. Kutlu, M.G., Brady, L.J., Peck, E.G., Hofford R.S., Sicilliano, C.A., Kiraly, D.D., Calipari, E.S. (2018). Granulocyte colony stimulating factor enhances reward learning through potentiation of mesolimbic dopamine system. Journal of Neuroscience, 38(41), 8845-8859.

3. Mervosh, N.L., Wilson, R., Rauniyar, N., Hofford, R.S., Kutlu, M.G., Calipari, E.S., Lam, T.T., Kiraly, D.D. (2018). Granulocyte-colony stimulating factor alters the proteomic landscape of the ventral tegmental area. Proteomes, 6(4), 35.

4. Zeid, D., Kutlu, M.G., & Gould, T.J. (2018). Differential effects of nicotine exposure on the hippocampus across lifespan. Current Neuropharmacology, 16(4), 388-402.

 

5. Kutlu, M.G., Zeid, D., Tumolo, J.M., & Gould, T.J. (2018). Pre-adolescent and adolescent mice are less sensitive to the effects of acute nicotine on extinction and spontaneous recovery. Brain Research Bulletin, 138, 50-55.

 

6. Kutlu, M.G., Marin, M. #, Tumolo, J.M., Kaur, N., VanElzakker, M., Shin, S.M., & Gould, T.J. (2018). Nicotine exposure leads to deficits in differential fear conditioning in mice and humans: a potential role of the subgenual anterior cingulate cortex. Neuroscience Letters, 673, 142-149.

 

7. Kutlu, M.G., Cole, R., Connor, D.A., Natwora, B., & Gould, T.J. (2018). TrkB receptor activation reverses the impairing effects of acute nicotine on contextual fear extinction. Journal of Psychopharmacology, 32(3), 367-372.

 

8. Kutlu, M.G., Tumolo, J.M., Cann, C., & Gould, T.J. (2018). Differential effects of α4β2 nicotinic receptor antagonists and partial-agonists on contextual fear extinction in male C57BL/6 mice. Psychopharmacology, 235, 1211-1219.

 

9. Oliver, C., Kutlu, M.G., Zeid, D., & Gould, T.J. (2018). Sex differences in the effects of nicotine on fear extinction. Biochemistry, Pharmacology, and Behavior, 165, 25-28.

 

10. Tumolo, J.M., Kutlu, M.G., & Gould, T.J. (2018). Chronic nicotine differentially alters spontaneous recovery of contextual fear in male and female mice. Behavioural Brain Research, 341, 176-180.

2017

1. Kutlu, M.G., Garret, B., Gadiwalla, S., Tumolo, J.M., & Gould, T.J. (2017). Acute nicotine downregulates long-term memory-associated hippocampal kinases during contextual fear extinction. Neurobiology of Learning and Memory, 145, 143-150.

 

2. Connor, D.A., Kutlu, M.G., & Gould, T.J. (2017). Nicotine disrupts safety learning through enhancing maladaptive trace associations mediated by dorsal hippocampus and medial prefrontal cortex. Journal of Psychopharmacology, 31(7), 934-944.

2016

1. Holliday, E., Nucero, P., Kutlu, M.G., Oliver, C., Connelly, P., Unterwald, E., & Gould, T.J. (2016). Long-term effects of chronic nicotine on emotional and cognitive behaviors and hippocampus cell morphology in mice: comparisons of adult and adolescent exposure. European Journal of Neuroscience, 44(10), 2818-2828.

 

2. Kutlu, M.G., & Gould, T.J. (2016). Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: contributions to development and maintenance of addiction. Learning and Memory, 23(10), 515-533.

 

3. Kutlu, M.G., Tumolo, J.M., Holliday, E., Garret, B., & Gould, T.J. (2016). Acute nicotine enhances spontaneous recovery of contextual fear and changes c-fos early gene expression in infralimbic cortex, hippocampus, and amygdala. Learning and Memory, 23(8), 405-414.

 

4. Kutlu, M.G., Oliver, C., Huang, P., Liu-Chen, L.Y., & Gould, T.J. (2016). Impairment of contextual fear extinction by chronic nicotine and withdrawal from chronic nicotine is associated with hippocampal nAChR upregulation. Neuropharmacology, 109, 341-348.

5. Kutlu, M.G., Braak, D.C., Tumolo, J.M., & Gould, T.J. (2016). Adolescent mice are less sensitive to the effects of acute nicotine on context pre-exposure than adults. Brain Research, 1642, 445-451.

 

6. Parikh, V., Kutlu, M. G., & Gould, T. J. (2016). nAChR dysfunction as a common substrate for schizophrenia and comorbid nicotine addiction: Current trends and perspectives. Schizophrenia Research, 171 (1-3), 1-15.

 

7. Kutlu, M. G., & Gould, T. J. (2016). Nicotinic modulation of hippocampal cell signaling and associated effects on learning and memory. Physiology & Behavior, 155, 162-171.

 

8. Kutlu, M. G., Holliday, E., & Gould, T. J. (2016). High-affinity α4β2 nicotinic receptors mediate the impairing effects of acute nicotine on contextual fear extinction. Neurobiology of Learning and Memory, 128, 17-22.

2015

1. Kutlu, M.G., & Gould, T.J. (2015). Nicotine modulation of fear memories and cellular substrates:  Implications of learning and anxiety disorders. Biochemical Pharmacology, 97(4), 498-511.

 

2. Hall, B. J., Slade, S., Allenby, C., Kutlu, M. G., & Levin, E. D. (2015). Neuro-anatomic mapping of dopamine D1 receptor involvement in nicotine self-administration in rats. Neuropharmacology, 99, 689-695.

 

3. Kutlu, M. G., Parikh, V., & Gould, T. J. (2015). Nicotine Addiction and Psychiatric Disorders. International Review of Neurobiology, 124, 171-208.

 

4. Leach, T.L., Holliday, E., Kutlu, M.G., & Gould, T.J. (2015). In C57BL/6J mice, withdrawal from chronic nicotine reduces thyroid hormone levels and levothyroxine treatment ameliorates nicotine withdrawal-induced deficits in hippocampus-dependent learning. Nicotine & Tobacco Research, 17(6), 690-696.

 

5. Kutlu, M.G., Ortega, L.A., & Gould, T.J. (2015). Strain-dependent performance in nicotine-induced conditioned place preference. Behavioral Neuroscience, 129(1), 37-41.

2014 & Older

1. Kutlu, M.G., Oliver, C., & Gould, T.J. (2014). The effects of acute nicotine on contextual safety discrimination. Journal of Psychopharmacology, 28(11), 1064-1070.

 

2. Rosenthal, M.Z., & Kutlu, M.G. (2014). Translation of associative learning models into extinction reminders delivered via mobile phones during cue exposure interventions for substance use. Psychology of Addictive Behaviors, 28(3), 863-871.

 

3. Kutlu, M.G., & Gould, T.J. (2014). An acute dose of nicotine delays extinction of contextual fear in mice. Behavioural Brain Research, 263, 133-137.

 

4. Kutlu, M. G., Burke, D., Slade, S., Hall, B. J., Rose, J. E., & Levin, E. D. (2013). Role of insular cortex D1 and D2 dopamine receptors in nicotine self-administration in rats. Behavioural Brain Research, 256, 273-278.

5. Kutlu, M.G., & Schmajuk, N.A. (2012). Solving Pavlov's puzzle: Attentional, associative and flexible configural mechanisms in classical conditioning. Learning & Behavior, 40, 269-291.

 

6. Kutlu, M.G., & Schmajuk, N.A. (2012). Deactivation and reactivation of the inhibitory power of a conditioned inhibitor: Testing the predictions of an attentional-associative model. Learning & Behavior, 40, 83-97.

 

7. Kutlu, M.G., & Schmajuk, N.A. (2012). Classical conditioning mechanisms can differentiate between seeing and doing in rats. Journal of Experimental Psychology: Animal Behavior Processes, 38(1), 84-101.

 

8. Schmajuk, N.A., & Kutlu, M.G. (2011). Latent inhibition and compound conditioning: A reply to Holmes and Harris (2009). Journal of Experimental Psychology: Animal Behavior Processes, 37(2), 254-260.

 

9. Schmajuk, N.A., & Kutlu, M.G. (2009).  The computational nature of associative learning. Behavioral Brain Science, 32, 223-224.

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